mysterious linkages between hepatitis c virus genotypes, interleukin-28b genotypes and viral clearance- a meta-analysis
نویسندگان
چکیده
conclusions there were significant linkages between hcv genotypes and il28b genotypes/alleles. patients with a favorable il28b and genotypes 1 and 4 hcv infection stand a better chance to clear hcv in the acute phase. objectives this meta-analysis was designed to determine the world-wide distribution patterns of il28b genotypes and alleles, and to find possible linkages between il28b and hcv genotypes. patients and methods manual and electronic databases were searched. critical appraisal was performed. according to the results of heterogeneity tests, we used fix/random model for the analysis. the data concerning patients’ ethnicity and hcv genotypes were analyzed by using statistical analysis software. results a total of 255 articles were found. after article review and quality assessment, 50 studies, including 18662 patients and 1313 healthy subjects, were analyzed. presence of hcv genotype 3 versus genotype 1 was significantly associated with a higher frequency of cc genotype and c allele, with an odds ratio (or) of 1.68 (95% ci: 1.44-1.99) and 1.49 (95% ci: 1.33-1.67), respectively. prevalence of the rs12979860 cc genotype among genotype 1 hcv infected patients of asian ethnicity was 69.48% (95% ci: 65.20-73.77), which was significantly higher than its prevalence [33.27% (95% ci: 28.88-37.67)] in the caucasian genotype 1 hcv infected patients. prevalence of rs12979860 tt genotype in the african-american genotype 1 hcv infected patients was the highest [36.20% (95% ci: 32.91-39.49)], and significantly different compared to all other ethnicities. background recent genome wide association studies (gwas) have shown important roles of single nucleotide polymorphisms (snp) near region of interleukin b 28 (il28b) gene in spontaneous and drug-induced clearance of hepatitis c virus (hcv) in genotype 1 hcv infection.
منابع مشابه
Mysterious Linkages Between Hepatitis C Virus Genotypes, Interleukin-28B Genotypes and Viral Clearance- A Meta-Analysis
BACKGROUND Recent genome wide association studies (GWAS) have shown important roles of single nucleotide polymorphisms (SNP) near region of interleukin B 28 (IL28B) gene in spontaneous and drug-induced clearance of hepatitis C virus (HCV) in genotype 1 HCV infection. OBJECTIVES This meta-analysis was designed to determine the world-wide distribution patterns of IL28B genotypes and alleles, an...
متن کاملCorrigendum to: Mysterious Linkages Between Hepatitis C Virus Genotypes, Interleukin-28B Genotypes and Viral Clearance-A Meta-Analysis [Published in Hepatitis Monthly. 2014 Mar; 14(3): e15895]
This corrigendum/addendum supplies corrected Table 1 which had missed rows for SNPs and genotypes/alleles.American Ethnicity a rs12979860 rs8099917 rs12979860 rs8099917 CC CT TT GG GT TT C T G T Caucasian HCV Genotype 1a Data are presented as mean (95%CI), %.
متن کاملcorrigendum to: mysterious linkages between hepatitis c virus genotypes, interleukin-28b genotypes and viral clearance-a meta-analysis [published in hepatitis monthly. 2014 mar; 14(3): e15895]
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TO THE EDITOR—We read the article by Seto et al [1] with interest. The authors investigated the correlation of HLA-DP and interleukin 28B (IL-28B) polymorphisms with hepatitis B surface antigen (HBsAg) seroclearance in hepatitis B virus (HBV) patients, and found that IL-28B haplotype CG (rs12979860/rs8099917) was associated with HBsAg clearance. The role of IL-28B polymorphisms in HBV has been ...
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عنوان ژورنال:
hepatitis monthlyجلد ۱۴، شماره ۳، صفحات ۰-۰
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